| 1949 | Establishment of Kyowa Hakko Kogyo |
| 1951 | Introduced production technology of Streptomycin, an anti-tubercular drug from US pharmaceutical company Merck & Co.,Inc.and succeeded in its mass production |
| 1956 | Success of isolation and commercially mass-production of the anticanser drug,MitomycinC. Invention of the process of L-Glutamic acid production by fermentation(a world first) Pioneered the major business industry of amino-acid fermentation. |
| 1958 | Invention of the process of L-Lysin production by fermentation. Release of a plant growth regulator,Gibberellin Kyowa(Contribution to production of seedless grapes) |
| 1969 | Establishment of Kyowa Hakko USA |
| 1973 | Establishment of Kyowa Hakko Europe |
| 1981 | Establishment of the Bio Business Headquarters |
| 2005 | Completion of the transition to an operating holding company(Phamaceuticals and Bio-chemicals are its main pillars) |
| 2007 | Announced a strategic alliance between Kyowa Hakko Group and Kirin Group. |
| 2008 | Establishment of Kyowa Hakko Bio (succeed Bio-Chemical business from Kyowa Hakko Kogyo) |