L-Citrulline is a non-proteinogenic amino acid.
Foodstuffs such as watermelon and bitter gourd contain high L-citrulline. L-Citrulline is also included in the human body. It is one of the components of the urea cycle, a process involved with the detoxification of ammonia. L-Citrulline exists as a free amino acid inside the body. When L-citrulline is converted to L-arginine, it produces the vasodilator “NO (Nitric Oxide)”.

  • “Reducing vascular endothelial dysfunction by suppressing lipoprotein oxidation in patients suffering from angina pectoris.” (Morita M, et al., Immun Endoc Metab Agents Med Chem. 2013;13(3).)
  • “Preventing swelling in lower limbs of young females.” (Morita et al. JPT 2012;40(9):787-794.)
  • “Improving vascular elasticity in middle aged males.” (Ochiai M, et al., Int J Cardiol. 2012 Mar 8;155(2):257-61.)
  • “Improved exercise performance (citrulline malate).” (Perez-Guisado J. et al., J Strength Cond Res. 24(5): 1215-22, 2010)
  • “Preventing pulmonary hypertension after surgery.” (Smith HA, et al., J Thorac Cardiovasc Surg. 2006;132(1):58-65.)
  • “Effective at reducing tiredness (citrulline malate).” (Bendahan D, et al., Br J Sports Med. 2002;36(4):282-9.)

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