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R&D

Healthcare Products Development Center

2016
  • Suzuki T, Morita M, Kobayashi Y, Kamimura A. Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study. J Int Soc Sports Nutr. 2016;13(6):1-8.
  • Suzuki T, Morita M, Kamimura A. The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males. Biosci Biotechnol Biochem. 2016:1-4.
2015
  • Sakamoto K, Mori A, Nakahara T, Morita M, Ishi K. Effects of long-term treatment of L-ornithine on visual function and retinal histology in the rats. Biol Pharm Bull. 2015;38(1):139-43.
  • Konishi Y, Koosaka Y, Maruyama R, Imanishi K, Kasahara K, Matsuda A, Akiduki S, Hishida Y, Kurata Y, Shibamoto T, Satomi J, Tanida M. L-Ornithine intake affects sympathetic nerve outflows and reduces body weight and food intake in rats. Brain Res Bull. 2015;111:48-52.
  • Akiduki S, Ito H, Morishita K, Kamimura A. A single-blind, parallel trial of L-hydroxyproline in healthy adult subjects. Urolithiasis. 2015;43(3):289-92.
  • Matsuo H, Iwamoto A, Otsuka T, Hishida Y, Akiduki S, Aoki M, Furuse M, Yasuo S. Effects of time of L-ornithine administration on the diurnal rhythms of plasma growth hormone, melatonin, and corticosterone levels in mice. Chronobiol Int. 2015;32(2):225-34.
  • Nakano M, Kamimura A, Watanabe F, Kamiya T, Watanabe D, Yamamoto E, Fukagawa M, Hasumi K, Suzuki E. Effects of orally administered pyrroloquinoline quinone disodium salt on dry skin conditions in mice and healthy female subjects. J Nutr Sci Vitaminol. 2015;61(3):241-6.
  • Mori A, Morita M, Morishita K, Sakamoto K, Nakahara T, Ishii K. L-Citrulline dilates rat retinal arterioles via nitric oxide- and prostaglandin-dependent pathways in vivo. J Pharmacol Sci. 2015;127(4):419-23.
  • McKinley-Barnard S, Andre T, Morita M, Willoughby DS. Combined L-citrulline and glutathione supplementation increases the concentration of markers indicative of nitric oxide synthesis. J Int Soc Sports Nutr. 2015;12(27):1-8.
  • McGlade E, Agoston AM, DiMuzio J, Kizaki M, Nakazaki E, Kamiya T, Yurgelun-Todd D. The effect of citicoline supplementation on motor speed and attention in adolescent males. J Atten Disord. 2015;6(16):1-14
  • Morita M, Ochiai M, Watanabe F, Adachi K, Morishita K. The relationship between plasma levels of L-arginine and NO after L-citrulline supplementation: A randomized, double-blind, placebo-controlled trial. Jpn Pharmacol Ther. 2015;43(7):969-75.
  • Ishikura F, Egawa M, Takano Y, Kumagai K, Suzuki T, Morita M. Effects of citrulline combined with tadalafil on monocrotaline-induced pulmonary hypertension in rats compared with arginine. J Nov Physiother. 2015;5(4):1-5.
  • Suzumura S, Tujioka K, Yamada T, Yokogoshi H, Akiduki S, Hishida Y, Tsutsui K, Hayase K. Comparison of the effects of ornithine and arginine on the brain protein synthesis rate in young rats. J Nutr Sci Vitaminol. 2015;61(5):417-21.
2014
  • Morita M, Hayashi T, Ochiai M, Maeda M, Yamaguchi T, Ina K, Kuzuya M. Oral supplementation with a combination of L-citrulline and L-arginine rapidly increases plasma L-arginine concentration and enhances NO bioavailability. Biochem Biophys Res Commun.  2014;454(1):53-7.
  • Koitaya N, Sekiguchi M, Tousen Y, Nishide Y, Morita A, Yamauchi J, Gando Y, Miyachi M, Aoki M, Komatsu M, Watanabe F, Morishita K, Ishimi Y. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women. J Bone Miner Metab. 2014;32(2):142-50.
  • Hotta Y, Shiota A, Kataoka T, Motonari M, Maeda Y, Morita M, Kimura K. Oral L-citrulline supplementation improves erectile function and penile structure in castrated rats. Int J Urol . 2014;21(6):608-12.
  • Nakamura E, Aoki M, Watanabe F, Kamimura A. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. Nutr J. 2014;13:85.
  • Kobayashi Y, Narita K, Chiba K, Takemoto H, Morita M, Morishita K. Effects of L-citrulline diet on stress-induced cold hypersensitivity in mice. Pharmacognosy Res. 2014;6(4):297-302.
  • Watanabe F, Hashizume E, Gertrude P Chan, Kamimura A. Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women trial in healthy women. Clin Cosmet Investig Dermatol. 2014;7;267-74.
  • Aoki M, Mochizuki M, Okamura T, Hatayama K, Nakamura A, Morishita K. A 4-week oral toxicity study of L-alanine in rats with a recovery period of 2 weeks. Fund Toxicol Sci. 2014;1(2):63-72.
  • Aoki M, Ishida S, Fukuzumi H, Morishita K. A 13-week feeding toxicity study of L-threonine in rats with a recovery period of 5 weeks. Fund Toxicol Sci. 2014;1(2):49-62.
2013
  • Yabuki Y, Shioda N, Yamamoto Y, Shigano M, Kumagai K, Morita M, Fukunaga K. Oral L-Citrulline administration improves memory deficits following transient brain ischemia through cerebrovascular protection. Brain Res. 2013;1520:157-67.
  • Morita M, Ochiai M, Watanabe F, Iizuka M, Yokoyama T, Kowatari Y, Morishita K. An open-label safety trial of kinetics and metabolic effects of orally-administered L-ornithine hydrochloride in healthy volunteers: A study of its effects, particularly on plasma L-ornithine levels and retinal function. Jpn Pharmacol Ther. 2013;41(8).
  • Shiota A, Hotta Y, Kataoka T, Morita M, Maeda Y, Kimura K. Oral L-Citrulline Supplementation Improves Erectile Function in Rats with Acute Arteriogenic Erectile Dysfunction. J Sex Med, 2013:10(10):2423–9.
  • Horiuchi M, Kanesada H, Miyata T, Watanabe K, Nishimura A, Kokubo T, Kirisako T. Ornithine ingestion improved sleep disturbances but was not associated with correction of blood tryptophan ratio in Japanese Antarctica expedition members during summer. Nutr Res. 2013; 33(7):557-64.
  • Koitaya N, Sekiguchi M, Tousen Y, Nishide Y, Morita A, Yamauchi J, Gando Y, Miyachi M, Aoki M, Komatsu M, Watanabe F, Morishita M, Ishimi Y. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women. J Bone Miner Metab. 2013
  • Yabuki Y, Shioda N, Yamamoto Y, Shigano M, Kumagai K, Morita M, Fukunaga K. Oral l-Citrulline administration improves memory deficits following transient brain ischemia through cerebrovascular protection. Brain Res. 2013;1520:157-67.
  • Hashizume E, Nakano T, Kamimura A, Morishita K. Topical effects of N-acetyl-L-hydroxyproline on ceramide synthesis and alleviation of pruritus. Clin Cosmet Investig Dermatol. 2013;6:43-9.
2012
  • Tujioka K, Yamada T, Abiko H, Aoki M, Morishita K, Hayase K, Yokogoshi H. Effect of Dietary Ornithine on the Brain Protein Synthesis Rate in Hypophysectomized Aged Rats. J Nutr Sci Vitaminol (Tokyo). 2012;58(5):346-53
  • Takada M, Sumi M, Maeda A, Watanabe F, Kamiya T, Ishii T, Nakano M, Akagawa M. Pyrroloquinoline quinone, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves impaired glucose tolerance in diabetic KK-Ay mice. Biochem Biophys Res Commun. 2012;428(2):315-20.
  • Morita M, Kobayashi Y, Iizuka M, Kondo S, Morishita K. The Effect of Oral L-citrulline Supplementation on Swelling of the Lower Legs in Young Females. Jpn Pharmacol Ther. 2012;40(9):787-794.
  • Tujioka K, Yamada T, Aoki M, Morishita K, Hayase K, Yokogoshi H. Dietary Ornithine Affects the Tissue Protein Synthesis Rate in Young Rats. J Nutr Sci Vitaminol (Tokyo). 2012;58(4):297-302.
  • Kirisako T, Morita Y, Hatta S, Tasumi K, Miura Y, Aoki M, Yonei Y. The Effect of Ornithine Ingestion on Skin Condition. Ther Res. 2012;33(8):1265-1281.
  • McGlade E, Locatelli A, Hardy J, Kamiya T, Morita M, Morishita K, Sugimura Y, Yurgelun-Todd D. Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women. Food Nutr Sci. 2012;3(6):769-773.
  • Ochiai M, Hayashi T, Morita M, Ina K, Maeda M, Watanabe F, Morishita K. Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men. Int J Cardiol. 2012;155(2):257-61.
  • Aoki M, Suto K, Komatsu M, Kamimura A, Morishita K, Yamasaki M, Takao T. Increasing Effect of an Oral Intake of L-Hydroxyproline on the Soluble Collagen Content of Skin and Collagen Fragments in Rat Serum. Biosci Biotechnol Biochem. 2012;76(6):1242-4.
  • Kurata K, Nagasawa M, Tomonaga S, Aoki M, Akiduki S, Morishita K, Denbow DM, Furuse M. Orally administered L-Ornithine reduces restraint stress-induced activation of the hypothalamic-pituitary-adrenal axis in mice. Neurosci Lett. 2012;506(2):287-91.
2011
  • Kurata K, Nagasawa M, Tomonaga S, Aoki M, Morishita K, Denbow DM, Furuse M. Orally administered L-ornithine elevates brain L-ornithine levels and has an anxiolytic-like effect in mice. Nutr Neurosci. 2011;14(6):243-8.
  • Demura S, Morishita K, Yamada T, Yamaji S, Komatsu M. Effect of L-ornithine hydrochloride ingestion on intermittent maximal anaerobic cycle ergometer performance and fatigue recovery after exercise. Eur J Appl Physiol. 2011;111(11):2837-43.
  • Morishita K, Demura S, Yamada T, Yamaji S, Aoki M, Kitabayashi T, Uchiyama M. The effect of ornithine ingestion on carbohydrate metabolism during rest after acute resistance exercise in healthy young males. Adv Biosci Biotechnol. 2011;2:28.
  • Furukawa-Hibi Y, Nitta A, Ikeda T, Morishita K, Liu W, Ibi D, Alkam T, Nabeshima T, Yamada K. The hydrophobic dipeptide Leu-Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF. Behav Brain Res. 2011;220(2):271-80.
  • Takasaki K, Morita M, Mishima K, Morishita K, Nogami A. Citidine-5-diphosphocholine Ameliorates the Impairment of Spatial Memory Induced by Scopolamine. J Health Sci 2011;57(5):432-435.
  • Kameda N, Okigawa T, Kimura T, Fujibayashi M, Asada T, Kinoshita R, Baba S, Morita M, Morishita K, Moritani T. The Effect of L-citrulline Ingestion on ECG QT Interval and Autonomic Nervous System Activity. J Physiol Anthropol. 2011;30(2):41-5.
  • Takasaki K, Uchida K, Fujikawa R, Nogami A, Nakamura K, Kawasaki C, Yamaguchi K, Morita M, Morishita K, Kubota K, Katsurabayashi S, Mishima K, Fujiwara M, Iwasaki K. Neuroprotective Neuroprotective effects of citidine-5-diphosphocholine on impaired spatial memory in a rat model of cerebrovascular dementia. J Pharmacol Sci. 2011;116(2):232-7.
  • Kurata K, Shigemi K, Tomonaga S, Aoki M, Morishita K, Denbow DM, Furuse M. L-Ornithine attenuates corticotropin-releasing factor-induced stress responses acting at GABAA receptors in neonatal chicks. Neuroscience. 2011;172:226-31.
2010
  • Demura S, Yamada T, Yamaji S, Komatsu M, Morishita K. The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise. Eur J Clin Nutr. 2010;64(10):1166-71.
  • Aoki M, Komatsu M, Ochiai M, Watanabe F, Igarashi M, Nonomura T, Tomita S, Umehara N, Nakai N, Morishita K. Healing Effects of Oral Administration of L-citrulline or L-ornithine in a Rat Pressure-ulcer Model. Jpn Pharmacol Ther. 2010;38(9):807-16.
  • Demura S, Yamada T, Yamaji S, Komatsu M, Morishita K. The effect of L-ornithine hydrochloride ingestion on human growth hormone secretion after strength training. Adv Biosci Biotechnol. 2010;1(1):7-11.
  • Ozaki A, Muromachi M, Sumi M, Sakai Y, Morishita K, Okamoto T. Emulsification of Coenzyme Q10 Using Gum Arabic Increases Bioavailability in Rat and Human and Improves Food-Processing Suitability. J Nutr Sci Vitaminol (Tokyo). 2010;56:41-47.
  • Kurauchi I, Shigemi K, Kabuki Y, Hamasu K, Yamane H, Aoki M, Kawada Y, Morishita K, Denbow DM, Furuse M. Central L-ornithine, but not polyamines, induces a hypnotic effect in neonatal chicks under acute stress. Nutr Neurosci. 2010;13(1):17-20.
  • Killgore WD, Ross AJ, Kamiya T, Kawada Y, Renshaw PF, Yurgelun-Todd DA. Citicoline affects appetite and cortico-limbic responses to images of high-calorie foods. Int J Eat Disord. 2010;43(1):6-13.
2009
  • Igarashi M, Komatsu M, Aoki M, Morishita K, Nonomura T, Tomita S, Umehara N, Nakai N. Wound Healing Effects of Oral Administration of Mixture Including L-arginine and L-glutamine on Functionality Evaluation of Amino Acid on the Low-protein Breeding Decubitus Ulcer Rat Model. Jpn Pharmacol Ther. 2009;37(9):745-50.
  • Watanabe F, Ozaki A, Morishita K, Kyoda M, Tomoda M, Kajimoto Y, Hayashida K. Evaluation of Food Containing Methylsulfonylmethane (MSM) and Chicken Cartilage Extract on Osteoarthritis-A Human Clinical Trial- Jpn Pharmacol Ther. 2009;37(7):597-610.
  • Tsuneyoshi Y, Sato M, Tomonaga S, Yamane H, Morishita K, Denbow DM, Furuse M. Oral administration of Excitin-1 (beta-alanyl-L-leucine) alters behavior and brain monoamine and amino acid concentrations in rats. Nutr Neurosci. 2009;12(4):175-82.
  • Sakakibara H, Miyashita T, Matsui A, Ozaki A, Suzuki A, Ikeda T, Morishita K, Shimoi K. Effects of St John's Wort extracts on corticosterone levels dysregulated by social isolation stress. J Tradit Med. 2009;26(2):86-92.
  • Koitaya N, Ezaki J, Nishimuta M, Yamauchi J, Hashizume E, Morishita K, Miyachi M, Sasaki S, Ishimi Y. Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women. J Nutr Sci Vitaminol (Tokyo). 2009;55:15-21.
2008
  • Komatsu M, Aoki M, Takehara I, Fukuhara I, Morishita K. Safety of Excess Intake of Vitamin K2 (Menaquinone-4)-containing Calcium Tablets in Healthy Volunteers. Jpn Pharmacol Ther. 2008;36(12):1189-95.
  • Komatsu M, Aoki M, Ohno M, Iizuka M, Morishita K. Efficacy and Safety of Long Term Intake of Vitamin K2 (Menaquinone-4)-containing Calcium Tablets in Healthy Volunteers. Jpn Pharmacol Ther. 2008;36(12):1179-88.
  • Sugino T, Shirai T, Kajimoto Y, Kajimoto O. L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism. Nutr Res. 2008;28(11):738-43.
  • Silveri MM, Dikan J, Ross AJ, Jensen JE, Kamiya T, Kawada Y, Renshaw PF, Yurgelun-Todd DA. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR Biomed. 2008;21(10):1066-75.
  • Tsuneyoshi Y, Yamane H, Tomonaga S, Morishita K, Denbow DM, Furuse M. Reverse structure of carnosine-induced sedative and hypnotic effects in the chick under acute stress. Life Sci. 2008;82(21-22):1065-9.
  • Furuse M, Tsuneyoshi Y, Tomonaga S, Yamane H, Morishita, K, Denbow DM. Central Administration of L-Ser-L-His and L-Ile-L-His Induced Sedative Effects Under an Acute Stressful Condition in Chicks. Lett Drug Design Discov. 2008;5:65-8.
2007
  • Tsuneyoshi Y, Tomonaga S, Asechi M, Morishita K, Denbow DM, Furuse M. Central administration of dipeptides, beta-alanyl-BCAAs, induces hyperactivity in chicks. BMC Neurosci. 2007;8:37.
2006
  • Tokuyama E, Shibasaki T, Kawabe H, Mukai J, Okada S, Uchida T. Bitterness suppression of BCAA solutions by L-ornithine. Chem Pharm Bull. (Tokyo) 2006;54(9):1288-92