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News

Kyowa Hakko USA Announces GRAS Self-Affirmation for the amino acid L-Citrulline

March 4, 2014

Kyowa Hakko USA Announces GRAS Self-Affirmation for the amino acid L-Citrulline

L-Citrulline helps support nitric oxide metabolism and protein synthesis

Kyowa Hakko U.S.A., Inc. (Kyowa Hakko USA), the wholly owned
subsidiary of KYOWA HAKKO BIO CO., LTD. (Kyowa), has announced it has
completed GRAS (Generally Recognized As Safe) self-affirmation for the
valuable amino acid L-Citrulline.

L-Citrulline is an amino acid that plays an important role in nitric
oxide (NO) metabolism and regulation. L-Citrulline is converted to
L-Arginine in the body to support L-Arginine and NO levels. Increased
production of NO promotes vascular dilation which improves oxygen and
blood circulation throughout the body. L-Citrulline is also expected
to relieve muscle fatigue through ammonia elimination. Antioxidant
action and heart protection are also known.

“We are extremely proud to announce GRAS for our amino acid
L-Citrulline, and look forward to working with manufactures to
incorporate it into foods and beverages,” said Dr. Toshikazu Kamiya,
President & CEO of Kyowa Hakko USA.

L-Citrulline is preservative-free, allergen-free, and contains no
artificial flavors or colors. Manufactured in the U.S. using a
proprietary fermentation process, L-Citrulline is an ultra-pure amino
acid that carries the Kyowa Quality logo, ensuring that this
ingredient is backed by our commitment to the highest manufacturing
standards.

L-Citrulline will be marketed by Kyowa Hakko USA as a food ingredient
in the United States for use at levels of 275 mg of
L-Citrulline/serving up to a maximum of 2000mg/day in various food
products, such as beverages and beverages bases; grain products and
pastas; and milk products.