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News

Publication of Citrulline on Journal of the International Society of Sports Nutrition

March 22, 2016

Publication of Citrulline on Journal of the International Society of Sports Nutrition

KYOWA HAKKO BIO CO., LTD. (President and CEO: Chikakuni Kotani), published a research article titled ‘Oral L-citrulline*1 supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study’ on Journal of the International Society of Sports Nutrition.

Summary
Many studies report that nitric oxide (NO) improves sport performance in human study. L-Citrulline is an amino acid present in the body and is a potent endogenous precursor of L-arginine, which is a substrate for NO synthase. Interestingly, it has been reported that oral supplementation of L-citrulline increases the plasma L-arginine level more effectively than L-arginine in healthy subjects. The aim of this study was to investigate the effect of oral supplementation of L-citrulline on cycling time trial performance in humans.
A randomized double-blind crossover study design was employed. Twenty-two well-trained males consumed 2.4 g/day of L-citrulline or placebo orally for 7 days, and took 2.4 g of L-citrulline or placebo 1 hour before a 4-km cycling time trial on Day 8. Time taken to complete the 4 km cycle, amino acid levels, and visual analog scale (VAS) scores was evaluated.
The results showed that L-citrulline supplementation significantly increased plasma L-arginine and reduced completion time by 1.5% (p < 0.05) compared to placebo. Moreover, L-citrulline significantly improved subjective feelings of muscle fatigue and concentration immediately after exercise.
We conclude that Oral L-citrulline supplementation reduced the time take to complete a cycle ergometer exercise trial.

Term
*1 L-Citrulline: Amino acid presents in the body and is a potent endogenous precursor of L-arginine, which is a substrate for NO synthase. L-Citrulline supplementation has been shown to exhibit various beneficial effects such as improving arterial stiffness, erectile function, and memory deficit through up-regulation of NO synthesis.

Reference
Journal of the International Society of Sports Nutrition. 13:6,2016.

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